I have, unfortunately there was no change.
While very true, this exact set up seemingly had no issues running up to 100+ mods at 600+ render distance for up to 140 hours of game play before this issue occurred. Id be willing to bet its a memory leak, but as to whether it is the vanilla game or any one of the mods I have installed is anyone's guess. Interestingly enough I still have the stutter even when my render distance is set to the absolute minimum, so I really doubt its anything to do with my specs not being up to snuff.
Thanks for taking the time to write this all out!
I do have a gaming mouse, however it is just a Steel Series that I did not install any extra software for as it worked fine out of the box.
I have attempted turning off VSync as well, along side turning it to "On-Sleep", and setting my FPS to unlimited; unfortunately none of the suggestions for toggling graphical settings worked for me, even working in increments down. The freeze appears regardless if I set to 'Pathetic' graphical settings, though it does appear slightly less abrupt.
The mods are where I am the most stumped; I have done almost everything you've suggested, even going so far as to whittle the entire list down to vanilla, and was still experiencing the same stutter to a degree. Even after a complete reinstall on an entirely different drive, making sure to delete as much of the already existing files as I could find, I still had the stutter. Its starting to become my White Whale, I'm afraid.
Though I have looked into private servers, I am not in the place where I can readily pay a monthly subscription service for stable solo game play.
Ultimately I am leaning towards the possibility of it being a memory leak. Unfortunately I am not very well versed in the business of using dev tools to log files. @LadyWYT Would you happen to know of any easy to follow lists somewhere on another forum post or wiki page perhaps that outlines how to go about doing this in a way that doesn't just generate a bunch of useless information?