I must be lucky, in that the 70 to 80 mods I use all work flawlessly together. Some people have WAY more than that, and they have no problems either.
I've had the game just over a week, and after trying different worlds to learn the ropes, then deleting them, my latest world has 120 hours in it. I'm making Iron Chain Mail now, plus some Iron weapons, but my tools are all still tin-bronze, for now. I got a big kick out of making Copper stuff, as well as Leather, and I was so excited making Tin-Bronze stuff! Iron has been a whole different ball game, and took ages to figure out, but I made it, after just pulling an all-nighter - I'm tired but happy! These old bones need a nap though. I need lots of Borax and Salt, though, so I'll have to get cracking when I wake up.